Metabolic events with spontaneous malignant hyperthermia
نویسندگان
چکیده
منابع مشابه
Malignant Hyperthermia
''Malignant Hypothermia'' syndrome is a rare, but dangerous occurrence, the aetiology of which is not known. Up to this date 180 cases have been reported. This syndrome i's seen generally in :male children over age of two years, and especially in adolescent males. Also those people with muscular abnormalities are more susciptable to this illnes'S. Anaesthetic agent such as halothane or muscular...
متن کاملSkeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility.
BACKGROUND Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise...
متن کاملExercise-Induced Rhabdomyolysis and Stress-Induced Malignant Hyperthermia Events, Association with Malignant Hyperthermia Susceptibility, and RYR1 Gene Sequence Variations
Exertional rhabdomyolysis (ER) and stress-induced malignant hyperthermia (MH) events are syndromes that primarily afflict military recruits in basic training and athletes. Events similar to those occurring in ER and in stress-induced MH events are triggered after exposure to anesthetic agents in MH-susceptible (MHS) patients. MH is an autosomal dominant hypermetabolic condition that occurs in g...
متن کاملSpontaneous occurrence of the disposition to malignant hyperthermia.
ONE characteristic of malignant hyperthermia (MH) is the autosomal-dominant mode of inheritance. This implies that at least one parent of an affected patient should be predisposed to MH. In this report, we describe two families in which MH susceptibility developed spontaneously through a neomutation. These families attracted attention because both parents of an MH-susceptible individual were di...
متن کاملMalignant Hyperthermia: The Spontaneous development of the MH-PSS Syndrome
Mating MH positive pigs to MH positive pigs produces an F1 generation that is highly stress susceptible. Recording the MUP shows MH + pigs have a higher u voltage than control pigs. Older MH+ pigs have an even higher u voltage than control pigs. The duration of the voltage spike is also increased in MH+ pigs versus control pigs and older MH+ pigs have even a longer duration of the voltage spike...
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ژورنال
عنوان ژورنال: Canadian Journal of Anaesthesia
سال: 1998
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03012921